Tell your doctor if you have severe breathing problems, enzyme disorders, serious liver disease, kidney disease, or abdominal/stomach problems in your medical history, as well as any personal or family history of substance abuse disorder and mentail/mood disorders. Discuss with your doctor, pharmacist, or physician if you are allergic to acetaminophen, caffeine, butalbital, other barbiturates, or xanthine derivatives, and if you have any other allergies. Only take this medication when clearly needed during pregnancy. This medication passes down in small amounts to breast milk. Consult your doctor before breastfeeding.